Isovaleric Acidemia as a Rare Cause for Bad Obstetric History
Published: September 1, 2021 | DOI: https://doi.org/10.7860/JCDR/2021/49124.15434
Sailatha Ramanujam, Shery Angel, Anuradha Coimbatore Ramachandran, Anu Bhargavi Basker
1. Professor, Department of Obstetrics and Gynaecology, Chettinad Hospital and Research Institute, Chennai, Tamil Nadu, India.
2. Associate Professor, Department of Obstetrics and Gynaecology, Chettinad Hospital and Research Institute, Chennai, Tamil Nadu, India.
3. Professor and Head, Department of Obstetrics and Gynaecology, Chettinad Hospital and Research Institute, Chennai, Tamil Nadu, India.
4. Postgraduate Student, Department of Obstetrics and Gynaecology, Chettinad Hospital and Research Institute, Chennai, Tamil Nadu, India.
Correspondence
Dr. Anu Bhargavi Basker,
Plot No-294, First Main Road, M.K.B Nagar, Chennai, Tamil Nadu, India.
E-mail: anubasker94@gmail.com
Isovaleric acidemia is an inborn error of metabolism, inherited as an autosomal recessive disorder, caused by deficiency of isovaleryl-Coenzyme A (CoA) dehydrogenase, leading to elevated plasma isovaleric acid and urine isovalerylglycine levels. Isovaleric acidemia is an unusual disorder with an incidence of 1:67,000 in India. Parents of the child are assumed to be carriers and the offsprings have a one in four (25%) chance of inheriting the disorder. The present article reports a 33-year-old, Gravida 3 Para 2 Live 0 (G3P2L0) at 38 week + 1 day, with previous two Lower Segment Caesarean Surgery (LSCS) and two neonatal deaths, who delivered a term boy baby with incidental finding of isovaleric acidemia at birth. Isovaleric acidemia could sometimes be a rare case for bad obstetric history and should be considered while evaluating a patient. Also, it is now possible to diagnose the condition by early prenatal tests and even before pregnancy by Preimplantation Genetic Diagnosis (PIGD) and by taking necessary steps.
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